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apalutamide will lower the level or effect of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medicines which have been CYP2C19 substrates may lead to decrease exposure to these medicines.ethinylestradiol will increase the stage or outcome of d